Other projects:

Project 1

Project 3

Project 4

fig1

C. elegans models of neurodegenerative diseases. Transgenic worms expressing human beta amyloid peptide (Aβ1-42) exhibit progressive and rapid paralysis phenotypes, demonstrating the toxicity of beta amyloid in C. elegans. Similarly, transgenic worms expressing progressively longer poly-glutamine (polyQ) repeats exhibit the appearance of motility defects that appear progressively earlier in adult life.

Project 2:

miRNA Function in Neurodegenerative Diseases

Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's are associated with aging, significantly impact the quality of life in the elderly population, and will be an increasingly important part of the medical healthcare as the population demographics shifts to an older population. Using C. elegans as a tractable model for these diseases, researchers have made progress in characterizing some of the molecular characteristics of these diseases, including the toxicity of the Aβ1-42 peptide in Alzheimer's and polyQ expansions in Huntington's. We are interested in understanding if the role of certain miRNAs associated with longevity and stress resistance extends to potential roles in the molecular profile of these diseases.